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After completing school in Australia Mendelsohn moved to the UK and secured his first job in 1974 at Milner Sound Fulham Rd. Chelsea, run by an ex BBC engineer John Milner.
Records on which he has worked have appeared in the British top ten charts. He is best known for producing the work of the Pet Shop Boys, and has also produced music for musicians including Elton John, Jimmy Page, Bob Marley, INXS, Level 42, Nik Kershaw and Paul McCartney.
Mendelsohn was nominated for Producer of the Year at the 1988 British Phonographic Industry awards. He currently resides in Melbourne, Australia, where he operates MoreNoiz Audio Production.